Fig. 3. Enflurane-induced changes in characteristics of inhibitory postsynaptic currents calculated from recordings on wild-type ( white ) and β3(N265M) mutant mice ( black ) neocortical neurons. ( A ) Enflurane (0.6 mm) causes a significant reduction of the amplitude of the mean inhibitory postsynaptic current in wild-type ( P < 0.05) but not in β3(N265M) mutant mice neurons. ( B ) Enflurane prolongs the fast component of the decay time (τfast) in a dose-dependent manner in the wild-type ( P < 0.05). In the β3(N265M) mutant, however, the values in the presence of 0.3 and 0.6 mm enflurane are not significantly different from control condition. ( C ) Regarding the slow component of the current decay (τslow), enflurane again only causes a significant prolongation in the wild-type ( P < 0.05) but not in neurons from β3(N265M) mutant mice. ( D ) In wild-type neurons, enflurane enhances the charge transfer in a dose-dependent manner ( P < 0.05), whereas there is only a slight increase in the presence of 0.6 mm enflurane in the β3(N265M) mutant. * P < 0.05 compared to control condition and to β3(N265M) mutant.