Fig. 6. Ketamine-induced inhibition of leukocyte recruitment is reverted by adenosine receptor antagonists. CD1 mice (n = 6 per treatment) were injected with saline (CT) or inoculated with a sublethal dose of E. coli . One hour before inoculation, mice were pretreated as indicated with saline (−); with an A2 receptor antagonist, DMPX (10 mg/kg); with an A2A receptor agonist, CGS-21680 (CGS, 2 mg/kg); and with a specific A2A receptor antagonist, ZM 241385 (ZM, 1 mg/kg). At the time of inoculation, mice were treated with saline (not indicated) or ketamine (KT, 10 mg/kg). Cell exudates were collected at 24 h by peritoneal lavage and counted. Results are presented as mean ± SE. * P < 0.05, ** P < 0.01. The figure depicts a representative experiment out of three performed.