Fig. 2. Dose-dependent effect of ketamine on mice survival. Sepsis was induced in CD1 mice by intraperitoneal injection of lethal doses of lipopolysaccharide (150 mg/kg). Mice were treated subcutaneously with increasing doses of ketamine at time of lipopolysaccharide injection. The mortality rate was evaluated at 96 h. n = 12 for the ketamine concentration point of 10 mg/kg, and n = 7 for other points.