American Society of Anesthesiologists

Fig. 3. Absence of effect of morphine (0.1 μm) on voltage-dependent activation and inactivation of L-type Ca2+current (ICa.L). ( A ) Representative current recordings used to determine voltage dependence of ICa.Linactivation. Cell was conditioned with 500-ms prepulses from holding potential of −80 mV to between −100 and 0 mV and back to −80 mV for 5 ms, then subjected to 300-ms test pulse to +10 mV. ( B ) Mean values of voltage-dependent activation and inactivation relations for ICa.L. No significant differences of V0.5and slope factor were observed for activation and inactivation of ICa.Lbefore (control; open circles ) and after application of 0.1 μm morphine ( filled circles ).

Fig. 3. Absence of effect of morphine (0.1 μm) on voltage-dependent activation and inactivation of L-type Ca²⁺current (I^Ca.L). ( A ) Representative current recordings used to determine voltage dependence of I^Ca.Linactivation. Cell was conditioned with 500-ms prepulses from holding potential of −80 mV to between −100 and 0 mV and back to −80 mV for 5 ms, then subjected to 300-ms test pulse to +10 mV. ( B ) Mean values of voltage-dependent activation and inactivation relations for I^Ca.L. No significant differences of V^0.5and slope factor were observed for activation and inactivation of I^Ca.Lbefore (control; open circles ) and after application of 0.1 μm morphine ( filled circles ).

This Feature Is Available To Subscribers Only