Fig. 3. Method used to analyze the effect of sevoflurane on postsynaptic glutamate receptor function. The graph shows the dose–response data of peak neuronal discharge frequency Fⁿto picoejection of  N -methyl-d-aspartate (NMDA) onto the neuron shown in  figure 2 . Linear regression analysis was performed, where the y-intercept was constrained to pass through control frequency (F^con) at the zero dose rate. The slope at 1 minimum alveolar concentration (MAC) sevoflurane (  dashed line with open circles ) was normalized to the slope at 0 MAC (  solid line with solid circles ) to allow for pooled analysis of the data. The original slope values are given.