Fig. 6. Schematic representation of dose-related effects according to age. The lowest dexmedetomidine dose associated with reversal of hyperalgesia (antihyperalgesia), significant prolongation of the righting reflex (sedation), and significant increases in the mechanical withdrawal threshold of the contralateral paw (antinociception) 15 min after epidural injection is represented for each age group. The dexmedetomidine dose is charted on a log2scale to allow differentiation of the effects at lower doses.