Fig. 2. Concentration–response curves to levcromakalim in the absence or in the presence of lidocaine or mexiletine (10−5, 3 × 10−5, 10−4m), obtained in the porcine coronary artery without endothelium. * Difference between control rings and rings treated with lidocaine or mexiletine is statistically significant ( P < 0.05).