Fig. 6. Overlap during the nuances of anesthesia loss of response (LOR)  versus first reaction (FR). Bispectral Index (BIS), state entropy (SE), response entropy (RE), mean arterial pressure (MAP), and heart rate (HR) during the steps loss of response (  right ) and first reaction (  left ). Shown are the same data as in  figure 5 . Each  spot represents one patient.