Fig. 8. Effects of isoflurane on desensitization. Currents were evoked by 2-s pulses of 1 mm γ-aminobutyric acid ( A–C ). Isoflurane enhanced profoundly macroscopic desensitization and prolonged deactivation only in receptors lacking a γ2subunit. ( Left column ) Averaged raw current traces. ( Right column ) Normalized currents. ( D ) Isoflurane increased significantly the extent of desensitization in α1β2- but not in γ2S- or γ2L-containing receptors. * P < 0.05, Student t test. Cont.-appl = continuous application; Ctrl. = control; Iso. = isoflurane.