Fig. 5. α¹β²γ^2S-containing receptors show substantial variability in responses to isoflurane. Cell 1 and cell 2 represent two extreme examples. (  A ) Effects of isoflurane on responses evoked by brief (10 ms) pulses of γ-aminobutyric acid (GABA). (  B ) Summary of isoflurane effects on peak amplitude of α¹β²γ^2S- (n = 28 cells)  versus α¹β²γ^2S-expressing cells (n = 6). (  C ) Normalized currents from panel  A . (  D ) Baseline desensitization profiles. (  E ) Degree of desensitization under control conditions and effects of isoflurane on deactivation and peak current amplitude show strong correlations in α¹β²γ^2Sreceptors. Ctrl. = control; Deact. = deactivation; Iso. = isoflurane; Pk^I= peak current.