Fig. 2. Narcotrend® index at loss of consciousness (LOC1), awareness reaction (ROC1), loss of consciousness after the awareness reaction (LOC2), and return of consciousness at the end of anesthesia (ROC2). The graphs show the 30-s transition intervals from the last response to command to the first command to which the patient did not respond (“squeeze hand”) (LOC) and  vice versa (ROC). Individual patient curves are shown for group 1 (  A ), sevoflurane/remifentanil (≤ 0.1 μg · kg⁻¹· min⁻¹); group 2 (  B ), sevoflurane–remifentanil (≥ 0.2 μg · kg⁻¹· min⁻¹); group 3 (  C ), propofol–remifentanil (≤ 0.1 μg · kg⁻¹· min⁻¹); and group 4 (  D ), propofol–remifentanil (≥ 0.2 μg · kg⁻¹· min⁻¹). At the transition intervals, numerous values were not calculated by the Narcotrend®. The figure shows between- and within-patient variability.