![Fig. 9. Simultaneous measurement of force and fluo-3 fluorescence, an index of [Ca2+], in a rat cardiac trabecula. Application of isoflurane decreased force and [Ca2+]. Restoration of the Ca2+transient amplitude by elevation of external [Ca2+] did not recover force, indicating that, in addition to decreasing Ca2+availability, the anesthetic decreased Ca2+-responsiveness of the contractile proteins. Adapted with permission from Hanley and Loiselle. 129](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/101/4/10.1097_00000542-200410000-00027/2/27ff9.png?Expires=1716582584&Signature=Ld9asCpMvqLMjHxVynm86C96GzqM62SWb3Up54LRD3vQwby6ThQpVJvBrrpRrkYxu9oVXlI0s7eTxjXuBNxYcD-ElqHKwVLH85nQQfnBiy6rBEp77ok6ogBBD2RBlTEM2w6W5j3kHlxw-ze3YRJb9j0ga~lGyW8sXZUCf764OA66uUm6b65ugofxfhkcfCwnCuJWLR-9bmFKQoBhShYyPk7w49dh~ZlWDVh~UMG7KLJt~KclT9ELORBgL5nlbu~cLyKb3REQ-hgR3T7YunlEpsHd47rjPNOxYiAP8TMKZd6PW4ewf19K41tPdPteRvGRlPPwSh12ODdS8FDibsiwnA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 9. Simultaneous measurement of force and fluo-3 fluorescence, an index of [Ca2+], in a rat cardiac trabecula. Application of isoflurane decreased force and [Ca2+]. Restoration of the Ca2+transient amplitude by elevation of external [Ca2+] did not recover force, indicating that, in addition to decreasing Ca2+availability, the anesthetic decreased Ca2+-responsiveness of the contractile proteins. Adapted with permission from Hanley and Loiselle. 129
