Fig. 4. L-type Ca²⁺currents (I^Ca,L) before, during and after application of sevoflurane at 21°C and 36°C. The sevoflurane concentrations were 2 minimum alveolar concentration (0.56 mm) at 21°C in panel  A , 2 minimum alveolar concentration (0.4 mm) at 36°C in panel  B , 1 minimum alveolar concentration (0.21 mm) at 36°C in panel  C , and 3 minimum alveolar concentration (0.61 mm) at 36°C in panel  D . Significant reductions of the peak current amplitudes are marked with an asterisk.