Fig. 3. Time course of lung lymph flow (Qlym), lymph–to–plasma protein concentration ratio (L/P), and lung lymph protein clearance (Clym) after endotoxin administration in sheep treated with and without ONO1714. Data are presented as mean ± SD. Open circle =endotoxin (ETX) plus ONO1714 treatment; closed circle =endotoxin alone. * P < 0.05, significant difference from baseline (BL). # P < 0.05, significant difference between groups with and without ONO1714 treatment.