Fig. 1. Time course of pulmonary arterial pressure (Ppa), left atrial pressure (Pla), and cardiac output (CO) after endotoxin administration in sheep treated with and without ONO1714. Data are presented as mean ± SD.  Open circle =endotoxin (ETX) plus ONO1714 treatment;  closed circle =endotoxin alone. *  P < 0.05 significant difference from baseline (BL). #  P < 0.05, significant difference between groups with and without ONO1714 treatment.