Fig. 1. Time course of pulmonary arterial pressure (Ppa), left atrial pressure (Pla), and cardiac output (CO) after endotoxin administration in sheep treated with and without ONO1714. Data are presented as mean ± SD. Open circle =endotoxin (ETX) plus ONO1714 treatment; closed circle =endotoxin alone. * P < 0.05 significant difference from baseline (BL). # P < 0.05, significant difference between groups with and without ONO1714 treatment.