Fig. 3. Plasma propofol concentrations in the lactated Ringer’s solution (LR) group, the hydroxyethyl starch group, and the threefold lactated Ringer’s solution (3LR) group before and during stepwise hemorrhage and fluid infusion with constant propofol infusion of 2 mg · kg⁻¹· h⁻¹. Regression parameters were calculated by the least-squares method using individual measured propofol concentrations taken from 0 to 180 min of propofol infusion. * Significant difference from the plasma propofol concentration at 180 min (0 ml) with each group. ** Significant difference from the plasma propofol concentration at 0 and 400 ml with each group. *** Significant difference from the values at 0, 400, and 800 ml. ### Significant difference between the LR and hydroxyethyl starch groups and between the LR and 3LR groups. † Significant difference between the 3LR and hydroxyethyl starch groups.