Fig. 7. Schematic illustration indicating the changes of the glycocalyx and the hypothesized changes in endothelial cell volumes and intercellular clefts under various experimental conditions. Interventions:Hep =  application of heparinase (without ischemia); I = ischemia (without enzyme application); I-Hep = application of heparinase during ischemia. HA = albumin; HES = hydroxyethyl starch. The thickness of the arrows  indicates the amount of extravasation. See text for further explanation.