Fig. 3. Regions with statistically significant (P < 0.05, corrected for multiple comparisons) ketamine-induced (300 ng/ml) relative regional glucose metabolic rate (rGMR) increases (cluster level) are presented in red . The increases are located in the frontal, temporal, and parietal cortices. The stereotactic coordinates are presented on the Anesthesiology Web site at http://www.anesthesiology.org. For details, see Materials and Methods, Data Analysis, Relative Voxel-based Analysis with SPM.