Table 4. Placebo-controlled Trials Comparing COX-2Is to Nonselective NSAIDs
* Reported trials are designed and statistically powered to detect differences in the primary outcome of pain intensity or relief, not adverse effects.
CEL = celecoxib; COX = cyclooxygenase; D = diclofenac; I = ibuprofen; K = ketorolac; N = naproxen; NSAID = nonsteroidal antiinflammatory drug; PAR = parecoxib; R = rofecoxib; =, <, > denote statistically no different, lesser, or greater.