Fig. 2. Antinociceptive (A ) and antiedematous (B ) activities of locally administered paracetamol (APAP) or indomethacin (INDO) in the rat formalin test. (A ) The two phases of nociceptive behavior were monitored 0 to 5 min (phase 1) and 20 to 40 min (phase 2) after intraplantar formalin injection (50 μL). The results are expressed as mean ± standard error of mean of the cumulative of biting and licking time during each phase. *P < 0.05 compared with the control group using analysis of variance followed by Student-Newman-Keuls test (n = 8). (B ) Paw edema measurements determined at the end of the late phase were converted into an increase in paw volume (percentage) compared with the preformalin injection values. *P < 0.05 compared with the vehicle group using analysis of variance followed by Student-Newman-Keuls test (n = 8).