Fig. 1. Typical time course of four behavioral indices (percentage of maximal possible effect [%MPE] for motor and normalized graded responses for proprioception, skin pinch, and deep pinch) of functional nerve block. The results from rats injected with 1.125 mg lidocaine in 0.2 ml (0.5625%) represent a typical time course (n = 16, mean ± SE). Peak effect (%MPE or graded response), duration of block, and area under the curve were calculated from graphs such as this one.