![Fig. 7. Summarized data for the effects of bisindolylmaleimide I (BIS) on phorbol 12-myristate 13-acetate (PMA)-induced changes in tension and [Ca2+]i(340/380 ratio) in ionomycin-pretreated pulmonary artery smooth muscle (PASM) strips. The PMA increased tension with a small concomitant decrease in [Ca2+]i(*P < 0.05 vs. control). Pretreatment with BIS abolished the PMA-induced changes in tension and [Ca2+]i(†P < 0.05 vs. PMA). Results are expressed as percentage changes relative to response to 60 mm KCl. n = 6, each.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/97/6/10.1097_00000542-200212000-00031/2/31ff7.png?Expires=1716426750&Signature=fHvhRKWtHreiKZv3lYlGoKm5zoODJtAJFC6DcQwyYni0GF1fnZl247OWyHbO97VHDx8D2MUCs-8GK5VvvlalLLdgDW293f5RK4-GOMP4mMNZi48eEhGYRBKS4AmeNeX8zDYYgB-cFI8Qy48xRLs0P2GnlnYz99~QEkCAUhYLgnm78YWLQNDOIqGL8px2vIRUwOSop0wIafRnXN4OXmk87kIw5IxiQ1-~UfsH61zPiVVOq06oHmivAddbGD-Hl9LzYGXydoLa3G7ejYrwxcBFJxJzO6X4AD3xQyWA81rrsfjbIb~NNRdosgqIQGS6~Bj23eHHG6ASgVILgyfRfv68dA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 7. Summarized data for the effects of bisindolylmaleimide I (BIS) on phorbol 12-myristate 13-acetate (PMA)-induced changes in tension and [Ca2+]i(340/380 ratio) in ionomycin-pretreated pulmonary artery smooth muscle (PASM) strips. The PMA increased tension with a small concomitant decrease in [Ca2+]i(*P < 0.05 vs. control). Pretreatment with BIS abolished the PMA-induced changes in tension and [Ca2+]i(†P < 0.05 vs. PMA). Results are expressed as percentage changes relative to response to 60 mm KCl. n = 6, each.
