Table 1. Vascular Dilution as Measured Directly from Blood Hemoglobin and Plasma Protein Concentration along with Indicator Dilution and Mass Balance Calculations
*P < 0.5 isoflurane versus conscious state.
Data shown for vascular dilution as measured directly from blood hemoglobin and plasma protein concentration along with indicator dilution and mass balance calculations of ΔPV (calculated from a baseline measurement of PV using indocyanine green), ΔISFV, and ∑UO at the end of a 20-min, 25 ml/kg infusion of 0.9% NaCl (T20) and at 40 min (T60) and 160 min (T180) after completing the infusion (T180).CMV, conscious, mechanically ventilated sheep; CSV, conscious, spontaneously ventilating sheep; Δ, net changes; ISFV, interstitial fluid volume; ISOMV, isoflurane-anesthetized, mechanically ventilated sheep; ISOSV, isoflurane-anesthetized, spontaneously ventilating sheep; PV, plasma volume; ∑UO, cumulative urinary output.