Fig. 10. Age-related differences in the effect of volatile anesthetics on the Na+dependence of Na+–Ca2+exchange (NCX)-mediated influx. The rate of Ca2+influx was determined after Na loading cells with one of three different extracellular Na+concentrations for a fixed period of time. Both anesthetics blunted the relation between Na+concentration and Ca2+influx rate in neonates (A and C ) as well as adults (B and D ), with the effect being greater in neonates. *Difference from control; §age-related differences; ‡difference between halothane and sevoflurane. Values are mean ± SD.