Fig. 3. Interaction between volatile anesthetics and BayK8644 (L-type Ca²⁺channel agonist). BayK8644 alone increased the intracellular Ca²⁺concentration ([Ca²⁺]ⁱ)response to electrical stimulation and blunted the inhibitory effect of halothane (A ) or sevoflurane (B ) (only 2 minimum alveolar concentration [MAC] data shown; middle bars in each group represent anesthetic effects without BayK8644). Selected significant differences are highlighted:*effect of adding BayK8644 to anesthetic-induced decrease of the [Ca²⁺]ⁱresponse; §age-related difference; †difference between halothane and sevoflurane. Values are mean ± SD.