Fig. 7 (A ) Assessment of nifedipine local anesthesia using a low-intensity tail-flick stimulus. The radiant-heat intensity was reduced to yield baseline tail-flick latencies of approximately 6 s. This allowed us to assess for any mild local anesthesia that was not observed with the high-intensity stimulus. Mice were injected with vehicle or nifedipine (28.8–2,888 μm) and assessed for local anesthesia 30 min later. (B ) Assessment of nicardipine local anesthesia using a low-intensity tail-flick stimulus. The radiant heat intensity was reduced to yield baseline tail-flick latencies of approximately 6 s. Mice were injected with vehicle or nicardipine (19.4–3,875 μm) and assessed for local anesthesia 30 min later.