Fig. 7. Effects of ketamine (0.1∼1 mm) on the Ca2+(3 and 30 μm)-activated contractions in the endothelium-denuded, fura-2–nonloaded strips. Each concentration of ketamine was applied for 2 min to the strips precontracted with Ca2+. (A ) A typical example. (B ) Analyzed data. The changes in force during application of ketamine (closed circles) were compared with the time control data (open circles). 0 min = time point when ketamine was applied. No significant differences were observed in the time-dependent changes in force during application of either 3 or 30 μm Ca2+between the control and ketamine-treated strips (P > 0.05, n = 4).