Fig. 1. Analog recordings of neurons in murine dorsal horn. Representative responses of a low-threshold (LT), wide dynamic range (WDR), and two nociceptive-specific (NS) neurons (each was analyzed separately) to calibrated mechanical stimuli in neurokinin-1 (NK1) receptor knockout mice are shown. Comparable neurons were found in the dorsal horn of wild-type mice. The stimuli used in each trace are indicated to the left. Bars on the top indicate the period of stimulation. Calibration bars for duration and amplitude are at the bottom right. BR = brush; vF(number) = von Frey filament (bending force in bars).