Fig. 2. Functional interaction map showing isoflurane-related changes in task-induced activation. Significant decrease in activation (z > 3.1 corresponding to P < 0.001) is visible in three distinct cortical regions: the right anterio-superior insula, the left intraparietal sulcus (ascending–horizontal branch), and right intraparietal sulcus (horizontal branch); a three-dimensional representation of these regions is given in figure 3. Voxels with a significant increase in task-induced activation were not found at this level of significance. Regions of significant task-induced activation that were not affected by isoflurane are shown in uniform blue (z > 5.5 corresponding to P < 10−7, uncorrected for multiple comparisons). L = left; R = right.