Fig. 3. Effects of CNS 5161A on neuronal damage in the hippocampal formation after cardiopulmonary bypass (CPB) and 2 h of hypothermic circulatory arrest. Group 3: CNS 5161A 0.6 mg/kg bolus and 1.0 mg · kg−1· h−1, significantly inhibited neuronal necrosis in CA1 and CA3 neurons (n = 5;P < 0.01 for group 3 vs groups 1 and 2). DG = dentate gyrus.