Fig. 2. Effects of CNS 5161A on c-Fos protein expression in the hippocampal formation after cardiopulmonary bypass (CPB) and 2 h of hypothermic circulatory arrest. Group 3: CNS 5161A 0.6 mg/kg bolus and 1.0 mg · kg−1· h−1, completely inhibited c-fos mRNA (data not shown) and c-Fos protein expression (n = 4; *P < 0.001 for group 3 vs group 1; #P < 0.01 for group 3 vs group 2). DG = dentate gyrus.