Table 4. Pharmacokinetic Model Parameter Estimates (Mean ± SE)

See Results for description of pharmacokinetic parameters.

Formula used: V^{2}= k^{12}/k^{21}· V^{1}; Cl^{1}= V^{1}· k^{10}; Cl^{2}= V^{1}· k^{12}

* The weight adjusted terms containing kg^{−1}as a unit need to be multiplied by the patient's weight in kg to calculate the parameter. For example an 80-kg patient, pre-CPB could have a V^{1}(l) = 80 kg · 0.149 l · kg^{−1}− 1.61 l = 10.3 l.

SE = standard error; CPB = cardiopulmonary bypass.