Table 1. Actions of Enflurane Alone and with Bicuculline on Glutamate-evoked Currents in Motor Neurons
During control conditions, there were no significant differences in enflurane sensitivity between +/+ and −/− mice. Bicuculline did not significantly increase current amplitudes. Bicuculline significantly attenuated the depressant actions of enflurane in motor neurons from +/+ but not −/− mice. When GABAAreceptors were blocked with bicuculline, currents in motor neurons from −/− mice were more sensitive to enflurane than those from +/+ mice. Current amplitudes as percentage of control; mean ± SEM (N).
* Significantly different from enflurane alone (P < 0.05). † Significantly different from wild type (P < 0.05).