Table 1. Enzyme Kinetic Values for Propofol 4-Hydroxylation by Liver Microsomes
Shown are the fitted values followed by the standard errors of the estimates.
* Best described by the two-enzyme kinetic model (equation 2), in which subscripts 1 and 2 indicate kinetic values for high- and low-affinity enzymes, respectively.
Km = Michaelis-Menten constant; Vmax = maximal reaction velocity.