Table 1. Binding Affinities of Benzodiazepines for Nucleoside Transporter as Determined by Competition for [³H]NBMPR Binding Sites in Membranes Prepared from Guinea Pig Ventricle or Porcine Striatum

Kⁱindicates the equilibrium dissociation constant. Values are mean ± SD of the results of n experiments performed in triplicate. Numbers in parentheses are mean p  Kⁱ± SD where p  Kⁱ=− log¹⁰(Kⁱ) and were determined by use of the Cheng-Prusoff equation.

P < 0.05:*, ventricle compared to striatum. Note: analysis of all binding studies gave Hill coefficients that were not significantly different than unity.