Table 3. Comparison with In Vivo Data
Peak plasma concentrations observed after bolus injection of the muscle relaxants in patients are compared with the concentrations required to provoke half-maximum histamine release (ED50histamine). Peak plasma concentrations were derived from references 43–48.
* Extrapolated from atracurium concentration.
† Ratios for atracurium and mivacurium were significantly lower, as compared with succinylcholine.
‡ Extrapolated from reference 44 (applied dose was 0.05 mg/kg).