Table 3. Parameters Derived from the Plasma Concentration–Time Curves

Data are mean ± SD.

* Mean of the concentrations measured after 24, 36, and 48 h infusion.

C^{end infusion}= total plasma concentration after 48 h infusion; AUC^0–48= area under the plasma concentration–time curve between 0 and 48 h; C^{u, end infusion}= unbound plasma concentration after 48 h infusion; C^{ss, u}= unbound steady-state concentration; Cl^u= unbound plasma clearance.