Table 4. Pharmacodynamic Descriptors of the Biphasic Electroencephalographic Effect–Concentration Relation in Control and Hypovolemic Animals at Intravenous Infusion of Propofol
Results are expressed as mean ± SD.
*P < 0.01, compared with the control group; multivariate multiple regression.
E0= electroencephalographic effect at baseline; EC50= concentration required to obtain 50% activation of the electroencephalographic effect; Emax= maximal activation of the electroencephalographic effect; ECm= concentration required to produce maximal electroencephalographic activation; ECb= concentration required to produce the baseline effect between maximal electroencephalographic activation and maximal electroencephalographic inhibition; ECi,50= concentration required to obtain 50% reduction of the electroencephalographic effect below baseline; ECi,90= concentration required to obtain 90% reduction of the electroencephalographic effect below baseline; keo= first-order rate equilibration constant; t1/2keo= equilibration half-life.