Table 5. Modeled Onset Times for Intravenous and Inhaled Morphine
Using the data from figure 5, the times to the maximum morphine effect-site concentrations (Cmax), and various fractional values of Cmax, were determined after intravenous or inhalation administration of 1 mg morphine. The lower value for Cmaxafter inhalation reflects the 59% bioavailability of this method of administration. Although the time to the peak effect is longer after inhalation, the times to 25% of the peak effect are similar.