Table 2. Parameters of the Inhalation Model

The inhalational model consisted of convolving the Bayesian estimates found in table 1(without the lag time) with the function: uptake (t) = F0(F1kae−kat+ (1 − F1)kbe−kbt) where F0represents the bioavailability of the inhaled drug, F1represents the fraction absorbed at rate ka, and (1 − F1) represents the fraction absorbed at rate kb. Values in parentheses represent the standard error. The total bioavailability is 59%. Forty-three percent of this is absorbed instantaneously (ka= 2.2 × 107) and 57% is absorbed with a half-life of 18 min (kb= 0.039).

Table 2. Parameters of the Inhalation Model
Table 2. Parameters of the Inhalation Model
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