Table 2. Parameters of the Inhalation Model

The inhalational model consisted of convolving the Bayesian estimates found in table 1(without the lag time) with the function: uptake (t) = F^{0}(F^{1}k^{a}e^{−kat}+ (1 − F^{1})k^{b}e^{−kbt}) where F^{0}represents the bioavailability of the inhaled drug, F^{1}represents the fraction absorbed at rate k^{a}, and (1 − F^{1}) represents the fraction absorbed at rate k^{b}. Values in parentheses represent the standard error. The total bioavailability is 59%. Forty-three percent of this is absorbed instantaneously (k^{a}= 2.2 × 10^{7}) and 57% is absorbed with a half-life of 18 min (k^{b}= 0.039).