Table 3. QRS Widening
The best model was the model with k12 and Emaxsignificantly different for all drugs, k21 and k10 identical for rac- and levobupivacaine and Css50similar for all three drugs (see table 2). Data are estimates of PK, PD, and rate dependence parameters (% coefficient of variation of parameter estimate). ω2is the variance of interindividual variability parameter (η). Data are given with two significant digits. The rate dependence of QRS widening was tested in the range 170–350 beats/min. k12, k21, and k10 are rate constants from central compartment to peripheral compartment, from peripheral to central compartment and elimination from central compartment, respectively. Emax and Css50are the calculated maximum QRS duration and perfusate steady state concentration leading to half Emax, respectively.