Table 3. QRS Widening

The best model was the model with k12 and E^maxsignificantly different for all drugs, k21 and k10 identical for rac- and levobupivacaine and Css⁵⁰similar for all three drugs (see table 2). Data are estimates of PK, PD, and rate dependence parameters (% coefficient of variation of parameter estimate). ω²is the variance of interindividual variability parameter (η). Data are given with two significant digits. The rate dependence of QRS widening was tested in the range 170–350 beats/min. k12, k21, and k10 are rate constants from central compartment to peripheral compartment, from peripheral to central compartment and elimination from central compartment, respectively. Emax and Css⁵⁰are the calculated maximum QRS duration and perfusate steady state concentration leading to half E^max, respectively.