Table 2. Estimated Values of 50% Inhibitory Concentrations (IC⁵⁰) for Block of hH1 Wild-type and Mutant Na⁺Channels by Bupivacaine Enantiomers

The IC⁵⁰values for block of wild-type channels were derived from concentration–inhibition experiments as described in figure 1B. The IC⁵⁰values for block of mutant channels were estimated as described in figure 6A.

* Indicates a statistically significant change in IC⁵⁰value compared with wild-type (P < 0.05).