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Table 1. Pharmacokinetic Parameters for Thiopental in Five Dogs

Values are presented as mean (SD).

* The volumes (V) of the central compartment (C), the nondistributive (ND) circuit, and the rapidly equilibrating (fast, F) and slowly equilibrating (S) tissues, and the volume of distribution at steady state (SS), which equals the sum of all volumes.

† The clearances (CI) of the ND circuit and the F and S tissues, elimination clearance (E), and the sum of all clearances (ΣCI), which, in the recirculatory model, equals the indocyanine green (dye dilution) cardiac output determined at the moment of marker injection.

‡ Infusion ΔAUC is the area between the predicted concentration history and the target concentration for the duration of a simulated 60-min targeted infusion (see text for details).

§ Different from the recirculatory model, model 3, and model 4 parameters (P < 0.05), as determined by Tukey test for multiple comparisons.

∥ Different from model 3 and model 4 parameters (P < 0.05), as determined by Tukey test for multiple comparisons.

# Different from the recirculatory model and model 4 parameters (P < 0.05), as determined by Tukey test for multiple comparisons.

** Different from model 2, model 3, and model 4 parameters (P < 0.05), as determined by Tukey test for multiple comparisons.

†† Different from model 4 parameters (P < 0.05), as determined by Tukey test for multiple comparisons.

NA = not applicable.

Table 1. Pharmacokinetic Parameters for Thiopental in Five Dogs
Table 1. Pharmacokinetic Parameters for Thiopental in Five Dogs
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