Table 2. Population Model Parameter Estimates for Normoxia Ventilation at a Fixed Petco²of 45 mmHg and the Ventilatory Response to Acute Hypoxia

* Parameter not included in the statistical model.

† C⁵⁰is an extrapolated value.

C²⁵and C⁵⁰= concentrations causing 25% and 50% reduction of responses; %CV = percent coefficient of variation; DODR = dose driving rate; k^el= drug elimination rate; Petco²= end-tidal pressure of carbon dioxide; PK/PD analysis = pharmacokinetic–pharmacodynamic analysis using pharmacokinetic data from the literature (see table 1); t^1/2k^e0= blood effect-site equilibration half-life.