Table 3. Effects of Isoflurane on Angiotensin II–induced Ca2+Mobilization in Spontaneously Hypertensive Rats
Effect of isoflurane (0.5–3%) on angiotensin II (1 μ m)–induced intracellular Ca2+mobilization in the presence (Na+-HEPES medium) and nominal absence of external Ca2+(Ca2+-free medium) and on Ca2+influx induced either by angiotensin II or thapsigarghin in vascular smooth muscle cells from spontaneously hypertensive rats. Results are expressed as percent of control values obtained in nontreated cells.
*P < 0.05,
†P < 0.001, and
‡P < 0.0001 for isoflurane-treated cells versus nontreated cells;
§P < 0.05,
∥P < 0.001,
#P < 0.0001 for spontaneously hypertensive versus Wistar-Kyoto rats.
n = number of cells/number of coverslips analyzed; NM = not measured.