Table 3. Effects of Isoflurane on Angiotensin II–induced Ca²⁺Mobilization in Spontaneously Hypertensive Rats

Effect of isoflurane (0.5–3%) on angiotensin II (1 μ m)–induced intracellular Ca²⁺mobilization in the presence (Na⁺-HEPES medium) and nominal absence of external Ca²⁺(Ca²⁺-free medium) and on Ca²⁺influx induced either by angiotensin II or thapsigarghin in vascular smooth muscle cells from spontaneously hypertensive rats. Results are expressed as percent of control values obtained in nontreated cells.

*P < 0.05,

†P < 0.001, and

‡P < 0.0001 for isoflurane-treated cells versus  nontreated cells;

§P < 0.05,

∥P < 0.001,

#P < 0.0001 for spontaneously hypertensive versus  Wistar-Kyoto rats.

n = number of cells/number of coverslips analyzed; NM = not measured.