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Table 1. Pharmacokinetic Parameters for Protocols 1 and 2

Mean ± standard deviation. No significant drug effect for any of the variables.

*P < 0.0001 versus  male subjects.

N = number of subjects; AUC = area under the curve; CL = clearance; Vd= volume of distribution; T1/2α= distribution time constant, bi-exponent model; T1/2β= elimination half time, bi-exponent model; V1= central compartment volume; V2= peripheral compartment volume.

Table 1. Pharmacokinetic Parameters for Protocols 1 and 2
Table 1. Pharmacokinetic Parameters for Protocols 1 and 2
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