Table 1. Pharmacokinetic Parameters for Protocols 1 and 2
Mean ± standard deviation. No significant drug effect for any of the variables.
*P < 0.0001 versus male subjects.
N = number of subjects; AUC = area under the curve; CL = clearance; Vd= volume of distribution; T1/2α= distribution time constant, bi-exponent model; T1/2β= elimination half time, bi-exponent model; V1= central compartment volume; V2= peripheral compartment volume.