Table 2. Effects of Chronic Hypoxia on Mitochondrial Oxidative Phosphorylation in Right and Left Ventricles
Experimental conditions are described in Materials and Methods. Basal, without adenosine diphosphate (ADP), and ADP-stimulated oxygen consumption rates supported by glutamate are expressed in nmol oxygen · min−1· mg dry weight−1. ATP synthesis rate is expressed in nmol ATP · min−1· mg dry weight−1. ATP-to-oxygen ratio (ATP/O) is calculated as the ratio of the rate of ATP synthesis to the rate of the concomitant respiration in the presence of ADP. Data are mean ± SD (n = 10).
*P < 0.05 versus normoxic LV.
†P < 0.05 versus hypoxic RV.
RV = right ventricular free wall; LV = left ventricular free wall.