Table 2. Pharmacokinetic Parameters of the Four Models and Parameters (Coefficients) Describing the Dependence of the Pharmacokinetic Parameters on Covariates
Data are (typical) values ± SE. Data in brackets are interindividual coefficients of variation (%).
* P < 0.01 versus model A.
† P < 0.01 versus model B.
‡ P < 0.01 versus models B and C.
§ Interindividual coefficient of variation could not be estimated, i.e. , it does not contribute significantly to the statistical model.
V1= volume of the central compartment; V2= volume of the shallow peripheral compartment; V3= volume of the deep peripheral compartment; CL = elimination clearance; CO = cardiac output; QI = Quetelet index.