On March 15, Moderna began enrolling 6,750 children from 6 months to 12 years of age in a study of its mRNA-1273 vaccine (NCT04796896). The study in children launched eight months after the launch of the pivotal Phase III study in adults (NCT04470427). Pfizer started enrollment of their mRNA vaccine, BNT162b2, last April (NCT04368728). As of today (March 21, 2021), Pfizer has not registered a study of the BNT162b2 in young children. The third EUA-approved vaccine in the United States, Johnson & Johnson's Ad26.COV2.S, began enrollment in September (NCT04505722). Johnson & Johnson has not registered a study of their vaccine in children.

Why are children always last?

Most children are only mildly symptomatic from SARS-CoV-2 (Sci Rep 2021;11:5760). However, some children get very ill, particularly if they develop multisystem inflammatory disease (MIS-C) (BMJ 2021;372:n385). The CDC summarizes the evidence succinctly. “Most children with COVID-19 have mild...

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