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A central venous catheter (or peripherally inserted central catheter) is usually used for prolonged administration of norepinephrine due to concerns about tissue damage if peripheral extravasation occurs. However, in a retrospective study that included over 14,000 patients who received an infusion of diluted norepinephrine (20 mcg/mL) via a peripheral intravenous (IV) catheter, extravasation was observed in only five patients, and none had complications requiring surgical or medical intervention [1]. These findings support previous evidence that dilute solutions of norepinephrine and other vasopressors...

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